Weeds actress Mary-Louise Parker has broken off her engagement with co-star Jeffrey Dean Morgan according to sources close to the 43-year-old actress.

The person, who requested anonymity because of the sensitive nature of the relationship, said the couple had differing lifestyles, but that Parker holds Morgan in the highest regard and hopes they remain friends.

Morgan, best known for his recurring role as Denny on “Grey’s Anatomy” and the deceased husband of Parker’s character on “Weeds,” began dating Parker in 2006. The pair briefly split last June but later reconciled. Parker, 43, and Morgan, 41, announced their engagement earlier this year.

The couple began dating in December 2006 after meeting on the set of Weeds. Parker has never been married. She was in a long relationship with Billy Crudup that produced her only child, William Atticus Parker.